Poor glycemic status as a risk factor for dementia in type 2 diabetes population: Findings from the Taiwan’s National Health Insurance Database
Main finding · DementiaResult — go to the resultAdjusted hazard ratio 2.01 95 % CI 1.58–2.68Authors' conclusion
In patients with T2D, PGS is associated with an increased risk of dementia, particularly in those experiencing significant fluctuations in glycemic levels.
Study context
- Population
- Patients with T2D, Taiwan's National Health Insurance Database, 2000–2015
- Participants
- 192,977 patients
- Exposure
- Poor glycemic status (PGS) vs no PGS in T2D
- PGSn = 57,893
- Outcome
- Dementia risk
Methodological detailspropensity score matching (1:1) based on sex, age, index year, and inclusion date, secondary analysis of Taiwan's National Health Insurance Database
- Propensity score matching (1:1) based on sex, age, index year, and inclusion date
- Secondary analysis of Taiwan's National Health Insurance Database
Main finding
Dementia
Adjusted hazard ratio
2.01
95 % CI 1.58–2.68
Events by group
PGS
7.5 %
4,342 of 57,893
PGSvs Without PGS
aHR 2.01 (95 % CI 1.58–2.68)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Risk (95 % CI) |
|---|---|
| Dementia by PGS typeHypoglycemia vs Without PGS | 1.56 (1.22–2.08) |
| Dementia by PGS typeHyperglycemia vs Without PGS | 1.64 (1.30–2.18) |
| Dementia by PGS typeMixed PGS vs Without PGS | 3.10 (2.48–4.12) |
Original publication
Poor glycemic status as a risk factor for dementia in type 2 diabetes population: Findings from the Taiwan’s National Health Insurance Database. Diabetes Res Clin Pract. Published 26 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →