Platelet-Derived Growth Factor B Is a Key Element in the Pathological Bone Formation of Ankylosing Spondylitis
Authors' conclusion
This study suggests that regulating PDGFB/PDGFRB signaling could be a novel therapeutic strategy to block key pathophysiological processes of AS.
Study context
- Population
- Ankylosing spondylitis (AS) patients and healthy controls (HC); human entheseal tissues from facet joints or spinous processes harvested at surgery; curdlan-treated SKG mice
- Comparison
- AS vs HC; PDGFRB agonist and antagonist in curdlan-treated SKG mice
- Outcome
- Role of PDGFB in enthesophyte formation of AS
Methodological detailsin vitro and in vivo models, human entheseal tissues, curdlan-treated SKG mice
- In vitro and in vivo models
- Human entheseal tissues
- Curdlan-treated SKG mice
Main finding
As reported in the abstract
- Platelet-derived growth factor B (PDGFB) levels elevated in AS sera and correlated with radiographic progression of AS in the spine
- Mature osteoclasts secreting PDGFB increased in AS vs HC and observed in bony ankylosis tissues of AS
- PDGFRB expression significantly elevated in spinous enthesis and facet joints of AS vs controls
- Recombinant PDGFB accelerated bone mineralization of enthesis cells, pronounced in AS; PDGFRB inhibition reduced PDGFB-induced mineralization
- PDGFRB inhibition attenuated arthritis severity and enthesophyte formation in curdlan-treated SKG mice
Original publication
Platelet-Derived Growth Factor B Is a Key Element in the Pathological Bone Formation of Ankylosing Spondylitis. J Bone Miner Res. Published 24 November 2022. doi:10.
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