Phosphate concentration is exceptionally high in seminal fluid and is linked with semen quality but not influenced by vitamin D and calcium supplementation
Authors' conclusion
Seminal fluid phosphate concentration may be of importance for reproductive function as infertile men with the lowest SF phosphate concentration had higher percentage of motile and morphologically normal spermatozoa. Serum phosphate concentration was not associated with seminal phosphate levels, and cholecalciferol and calcium supplementation did not influence SF phosphate.
Study context
- Population
- Infertile men
- Participants
- 307 men
- Comparison
- Cholecalciferol plus calcium vs placebo
- Primary endpoint
- Change in SF phosphate (predefined secondary endpoint of the trial; trial primary endpoint was semen parameters)
- Follow-up
- 150 days
Methodological detailssingle-centre, double-blind
- Single-centre
- Double-blind
Primary result
As reported in the abstract
Placebo
21.4
median · IQR 15.9–28.4
Vitamin D + calcium
21.1
median · IQR 14.5–29.8
Secondary outcomes
Baseline seminal fluid (SF) vs serum phosphate
- SF phosphate, median (IQR)
- 24.0 mmol/L [IQR 17, 30]
- Serum phosphate, median (IQR)
- 0.93 mmol/L [IQR 0.83, 1.05]
- SF phosphate 25-fold higher than serum, not associated with serum phosphate
Motile spermatozoa (AB%), SF phosphate ≥29 vs <19 mmol/L · baseline
- Fewer motile spermatozoa with SF phosphate ≥29 mmol/L vs <19 mmol/L
- median 27% [IQR 14, 39] vs 37% [IQR 17, 56]; P = .007
Morphologically normal spermatozoa, SF phosphate ≥29 vs <19 mmol/L · baseline
- Fewer morphologically normal spermatozoa with SF phosphate ≥29 mmol/L vs <19 mmol/L
- 1.9% [IQR 0.8, 3.8] vs 2.5% [IQR 1.4, 6.5]; P = .014
Original publication
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