Pelvis Magnetic Resonance Imaging to Diagnose Familial Partial Lipodystrophy
Authors' conclusion
The combined use of gluteal fat thickness and pubic/gluteal fat ratio from pelvic MRI is a promising method to diagnose FPLD that can reliably identify FPLD in women. Our findings need to be tested in larger populations and prospectively.
Study context
- Population
- Lipodystrophy cohort (median age 32 [24–44]; 48 females, 11 males) and age- and sex-matched controls; additional dataset of 289 consecutive patients59 lipodystrophy, 29 controls
- Comparison
- Pelvic magnetic resonance imaging (MRI) gluteal fat thickness ≤13 mm plus pubic/gluteal fat ratio ≥2.5 for diagnosis of familial partial lipodystrophy (FPLD)
- Outcome
- Diagnostic accuracy for FPLD, overall cohort
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Performance
As reported in the abstract
| Test or model | Sensitivity | Specificity |
|---|---|---|
| Gluteal fat ≤13 mm + pubic/gluteal ratio ≥2.5 | 96.67% (95% CI, 82.78-99.92) | 91.38% (95% CI, 81.02-97.14) |
Gluteal fat ≤13 mm + pubic/gluteal ratio ≥2.5
Sensitivity96.67% (95% CI, 82.78-99.92)
Specificity91.38% (95% CI, 81.02-97.14)
- ROC-derived potential cut-point of gluteal fat thickness for FPLD diagnosis
- ≤13 mm
Further findings
| Outcome | Values |
|---|---|
| Diagnosis of FPLD, females, gluteal fat ≤13 mm + pubic/gluteal fat ratio ≥2.5 | Gluteal fat ≤13 mm + pubic/gluteal ratio ≥2.5 sensitivity 100.00% (95% CI, 87.23-100.00) · specificity 90.00% (95% CI, 76.34-97.21) |
FPLD vs no lipodystrophy, larger dataset of random patients (combined approach)
- Sensitivity
- 96.67% (95% CI, 82.78-99.92)
- Specificity
- 100.00% (95% CI, 98.73-100.00)
FPLD vs no lipodystrophy, larger dataset of random patients, women only
- Sensitivity
- 100.00% (95% CI, 87.23-100.00)
- Specificity
- 100.00% (95% CI, 97.95-100.00)
Comparison with expert radiologist readouts
- Performance of gluteal fat thickness and pubic/gluteal fat thickness ratio comparable to readouts by radiologists with expertise in lipodystrophy
Original publication
Pelvis Magnetic Resonance Imaging to Diagnose Familial Partial Lipodystrophy. J Clin Endocrinol Metab. Published 21 February 2023. doi:10.
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