Patterns of initial and first‐intensifying antidiabetic drug utilization among patients with type 2 diabetes mellitus in Scotland, 2010–2020: A retrospective population‐based cohort study
Authors' conclusion
An overall increasing trend in prescribing the newer ADD classes compared to older ADDs was observed. However, metformin remained the most commonly prescribed first-line ADD, while SGLT2 inhibitors replaced SUs as the most common add-on therapy to initial metformin use in 2019.
Study context
- Population
- Patients with T2D who received antidiabetic drugs (ADDs) between January 2010 and December 2020 in Scotland
- Participants
- 145,909 new ADD users
- Outcome
- Utilization and prescribing patterns of ADDs at treatment initiation and first intensification
Methodological detailslinked routinely collected data
- Linked routinely collected data
Main finding
As reported in the abstract
- Single ADD at first treatment initiation
- N = 132 382 (≈91%)
- Metformin as most often prescribed monotherapy
- N = 118 737, 89.69%
- Treatment intensified with ≥1 additional ADD after metformin or sulphonylurea (SU) monotherapy
- 50 731 (39.40%)
- Intensified after initial metformin
- 46 730/118 737, 39.36%
- Intensified after initial SU
- 4001/10 029, 39.89%
- Initial-metformin users intensified with single ADDs
- 45 963/46 730; 98.36%
- Initial-SU users intensified with single ADDs
- 3894/4001; 97.33%
- SUs as most common first-intensifying monotherapy after initial metformin
- 22 197/45 963; 48.29%
- In 2019, SGLT2i replaced SUs as add-on to metformin: SGLT2i
- 2039/6065, 33.62%
- In 2019, SUs as add-on to metformin
- 1924/6065, 31.72%
- Metformin as most frequently added monotherapy to initial SU
- 2924/3894, 75.09%
Observational data: associations, not effects.
Original publication
Patterns of initial and first‐intensifying antidiabetic drug utilization among patients with type 2 diabetes mellitus in Scotland, 2010–2020: A retrospective population‐based cohort study. Diabetes Obes Metab. Published 1 April 2024. doi:10.
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