Ovarian reserve and endothelial health in healthy reproductive-age women
Authors' conclusion
In this longitudinal cohort of women with normal ovarian aging, baseline ovarian reserve markers of AMH and AFC were positively associated with endothelial function as a continuous outcome. Baseline ovarian reserve markers were not related to most secondary outcomes of cellular aging and metabolic risk.
Study context
- Population
- Healthy reproductive-age women from the Ovarian Aging Study (OVA); mean age 35.4 years at baseline ovarian reserve measurement and 45.1 years at endothelial function measurement
- Participants
- 322 women
- Outcome
- Endothelial function: Endothelial and Peripheral Arterial Tone reactive hyperemia index (RHI) score, in relation to baseline ovarian reserve markers (AMH, antral follicle count)
- Follow-up
- Average of 9.7 years after baseline
Methodological detailscommunity-based, longitudinal
- Community-based
- Longitudinal
Main finding
As reported in the abstract
Coefficient
0.052
95% CI 0.008–0.096P = 0.02
Antimüllerian hormone (AMH)
Coefficient
0.017
95% CI 0.001–0.032P = 0.04
Antral follicle count
Observational data: associations, not effects.
Secondary outcomes
Metabolic syndrome by antral follicle count, fully adjusted
| OR (95% CI) | P value | ||
|---|---|---|---|
| Antral follicle count | 0.92 (0.86–0.99) | P = 0.02 | |
| 0.512Odds ratio (log scale) |
Other secondary outcomes (AHA PREVENT score, metabolic syndrome, telomere length, mitochondrial DNA)
- Only statistically significant secondary result was the association of fully adjusted antral follicle count with metabolic syndrome
Sensitivity analysis, premenopausal cohort
- Similar findings in the premenopausal cohort
- N = 246
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →