Outdoor walking, genetic predisposition, and the risk of incident osteoporosis among older adults: A prospective large population-based cohort study
Authors' conclusion
A significant negative correlation exists between an extended period of daily outdoor walking and osteoporosis incidence risk. This correlation is particularly pronounced among individuals with low genetic risk.
Study context
- Population
- Older adults without osteoporosis at baseline, followed up until December 31, 20214,586 osteoporosis cases
- Participants
- 24,700 adults
- Exposure
- Longer vs shorter duration of daily outdoor walking
- Outcome
- Incident osteoporosis
Methodological detailslarge population-based, genetic risk score (14 SNPs), Genetic risk score comprised of 14 single-nucleotide polymorphisms
- Large population-based
- Genetic risk score (14 SNPs)
- Genetic risk score comprised of 14 single-nucleotide polymorphisms
Main finding
As reported in the abstract
median follow-up 37.3 months
Hazard ratio (95% CI)
>30 BUT ≤60 MIN/DAY
0.83(0.72–0.95)
>60 MIN/DAY
0.60(0.39–0.92)
Observational data: associations, not effects.
Further findings
Osteoporosis risk by genetic risk (subgroups)
- Low genetic risk: osteoporosis risk exhibited a declining trend
- High genetic risk: walking outside >60 min/day tended to have the lowest overall osteoporosis risk
Original publication
Outdoor walking, genetic predisposition, and the risk of incident osteoporosis among older adults: A prospective large population-based cohort study. Osteoporos Int. Published 21 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →