Obesity and metabolic dysfunction correlate with background parenchymal enhancement in premenopausal women
Main finding · BPEResult — go to the resultΔ 143.1 cm² 95% CI 49.5–236.7Authors' conclusion
In premenopausal women at high risk of breast cancer, increased BPE is associated with obesity, insulin resistance, leptin, and adiponectin.
Study context
- Population
- Premenopausal women at high risk of breast cancer
- Participants
- 59 women
- Exposure
- Obesity vs no obesity
- Outcome
- BPE (volume and intensity of enhancing fibroglandular breast tissue on dynamic contrast-enhanced MRI)
Main finding
BPE
Δ
143.1 cm²
95% CI 49.5–236.7
P = 0.003
By group
Obesityvs No obesity
Δ 143.1 cm² (95% CI 49.5–236.7); P = 0.003
As reported in the abstract
- BMI correlation with background parenchymal enhancement (BPE)
- r = 0.69; p < 0.001
Observational data: associations, not effects.
Further findings
Body composition and metabolic correlates of BPE
- Total body fat mass
- r = 0.68; p < 0.001
- Body fat percentage
- r = 0.64; p < 0.001
- Visceral adipose tissue area
- r = 0.65; p < 0.001
- Subcutaneous adipose tissue area
- r = 0.60; p < 0.001
- Insulin
- r = 0.59; p < 0.001
- Glucose
- r = 0.35; p = 0.011
- HOMA-IR
- r = 0.62; p < 0.001
- Leptin
- r = 0.60; p < 0.001
- Adiponectin (negative correlation)
- r = −0.44; p < 0.001
- Plasma inflammation and lipid biomarkers and urinary sex hormones not correlated with BPE
Original publication
Obesity and metabolic dysfunction correlate with background parenchymal enhancement in premenopausal women. Obesity (Silver Spring). Published 11 January 2023. doi:10.
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