Multicenter Comparison of Computerized Insulin Sensitivity Coefficient and Paper-Based Intravenous Insulin Protocols
Authors' conclusion
A computerized ISC-based insulin infusion protocol resulted in more blood glucose values in target range and lower rates of hypoglycemia compared with paper-based protocols.
Study context
- Population
- Critically ill adults initiated on intravenous (IV) insulin infusion, 13 institutions
- Participants
- 237 vs 207
- Comparison
- Computerized insulin sensitivity coefficient (ISC)-based insulin infusion calculator protocol vs paper-based IV insulin infusion protocols
- Post-interventionn = 237
- Pre-interventionn = 207reference
- Outcome
- Percentage of blood glucose levels within target range (80-180 mg/dL)
Methodological detailsmulticentre, 13 institutions
- Multicentre
- 13 institutions
Main finding
As reported in the abstract
Blood glucose values in range (80-180 mg/dL)
| Group | Value | Blood glucose values |
|---|---|---|
| Pre-intervention | 73% | 6313 |
| Post-intervention | 78.3% | 7870 |
Value
Pre-intervention73%
Post-intervention78.3%
Blood glucose values
Pre-intervention6313
Post-intervention7870
- Post-intervention vs Pre-intervention: P < 0.01
Secondary outcomes
Hyperglycemia (>200 mg/dL)
P < 0.01
Severe hyperglycemia (>250 mg/dL)
P < 0.01
Safety
Hypoglycemia (<70 mg/dL)
P < 0.01
Severe hypoglycemia (<54 mg/dL)
P = 0.24
Severe hypoglycemia (<54 mg/dL)
- There was no difference in severe hypoglycemia
Original publication
Multicenter Comparison of Computerized Insulin Sensitivity Coefficient and Paper-Based Intravenous Insulin Protocols. J Diabetes Sci Technol. Published 15 July 2026. doi:10.
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