Mobile App–Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes: A Randomized Clinical Trial
Authors' conclusion
In this randomized clinical trial of adults with uncontrolled T2D in China, a mobile message-based intervention resulted in a modest improvement in HbA1c and SBP in patients with diabetes compared with usual care. These results suggest that mobile message-based strategies for improving glycemic control and CVD risk factors should be considered for adults with T2D.
Study context
- Population
- Adults with uncontrolled T2D comorbid with CVD risk factors, 5 clinical centers in China; 67.4% men, mean age 50.1 years, mean hemoglobin A1c (HbA1c) 10.2%
- Participants
- 819 adults
- Comparison
- Mobile message-based intervention vs usual care
- Interventionn = 410
- Usual caren = 409reference
- Primary endpoint
- Mean changes in HbA1c, low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP)
- Follow-up
- Across 12 months
Methodological detailsmulticentre, Data collected November 2018 to March 2022; analysed January to June 2023
- Multicentre
- Data collected November 2018 to March 2022; analysed January to June 2023
Primary result
As reported in the abstract
12 months
Intervention
−2.8
95% CI −2.9%–-2.6% · % (HbA1c change)
Usual care
−2.5
95% CI −2.7%–-2.3% · % (HbA1c change)
Net group difference, HbA1c, % (95% CI)
Between Intervention and Usual care
−0.3(−0.5% to −0.0%)
Net group difference, LDL-C, mg/dL (95% CI)
Between Intervention and Usual care
0.9(−4.5 to 6.2)
Net group difference, SBP, mm Hg (95% CI)
Between Intervention and Usual care
−2.4(−4.3 to −0.4)
Secondary outcomes
Controlled HbA1c · 12 months · significantly higher with intervention
P = 0.04
Original publication
Mobile App–Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes: A Randomized Clinical Trial. JAMA Netw Open. Published 2 September 2025. doi:10.
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