MicroRNAs modify relationships between hemoglobin A1c and race and ethnicity
Authors' conclusion
We identified microRNAs that modify associations between self-reported categories of race and ethnicity and HbA1c, potentially reflecting confounding of theses associations by socioenvironmental factors, geographic ancestry, and other individual-level characteristics.
Study context
- Population
- DPP trial participants with microRNA data available at baseline; subset with longitudinal microRNA data150 with longitudinal data
- Participants
- 1,000 participants
Methodological detailscross-sectional and longitudinal analyses, in-silico analyses, exploratory analysis
- Cross-sectional and longitudinal analyses
- In-silico analyses
- Exploratory analysis
Primary result
As reported in the abstract
microRNAs modifying associations between race and ethnicity categories and HbA1c
Modified associations between race and ethnicity categories and HbA1c at baseline
miR-29b
Longitudinal modification
miR-92a, miR-146a
Further findings
- Modifying microRNAs also associated with socioenvironmental factors incl. nutrition, income, education and exercise
- Exploratory models
Original publication
MicroRNAs modify relationships between hemoglobin A1c and race and ethnicity. Diabetes Res Clin Pract. Published 17 February 2026. doi:10.
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