Methylglyoxal‐derived hydroimidazolone ( MG ‐ H1 ) is a novel marker of insulin resistance in Japanese individuals, disturbing insulin signalling via mTORC2 in cultured myocytes
Authors' conclusion
In clinical study findings revealed that postprandial MG-H1 was a novel marker of insulin resistance in Japanese individuals, and in vitro findings using cultured C2C12 skeletal myocytes suggested that MG-H1 disturbs insulin signalling via the mechanisms of mTORC2 activation.
Study context
- Population
- Japanese individuals with and without T2D
- Participants
- 19 vs 19
- Comparison
- T2D vs non-DM; MG-H1 vs insulin resistance
- T2DMn = 19
- non-DMn = 19reference
- Outcome
- Correlation of postprandial MG-H1 and AUC of MG-H1 in meal tolerance test (MTTs) with glucose disposal rate (GDR) in clamp
Methodological detailsmeal tolerance test, hyper-insulinemic-euglycemic clamp, in vitro C2C12 skeletal myocytes
- Meal tolerance test
- Hyper-insulinemic-euglycemic clamp
- In vitro C2C12 skeletal myocytes
Main finding
As reported in the abstract
| Group | Value | p |
|---|---|---|
| T2DM | r −0.72 | p < 0.001 |
| non-DM | r −0.54 | p < 0.05 |
Value
T2DMr −0.72
non-DMr −0.54
p
T2DMp < 0.001
non-DMp < 0.05
Further findings
In vitro effects of MG-H1 in C2C12 skeletal myocytes
- Pre-treatment with MG-H1 inhibited insulin-stimulated Akt phosphorylation and glucose uptake, via mTORC2 activation
Original publication
Methylglyoxal‐derived hydroimidazolone ( MG ‐ H1 ) is a novel marker of insulin resistance in Japanese individuals, disturbing insulin signalling via mTORC2 in cultured myocytes. Diabetes Obes Metab. Published 23 January 2026. doi:10.
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