Maternal exposure to extreme high‐temperature, particulate air pollution and macrosomia in 14 countries of Africa
Authors' conclusion
Maternal exposure to EHT, PM2.5 during pregnancy was associated with an increased risk of macrosomia in Africa.
Study context
- Population
- Births and mothers in the Seventh Demographic and Health Survey (DHS), 14 countries of Africa; macrosomia defined as birth weight ≥ 4000 g
- Participants
- 106,382 births
- Exposure
- Maternal exposure to extreme high-temperature (EHT) and PM2.5 vs lower exposure
- Outcome
- Macrosomia (birth weight ≥ 4000 g)
Methodological detailsSeventh Demographic and Health Survey (DHS), 14 countries of Africa, Cox proportional risk regression, restricted cubic spline, Interplot interaction model, stratified analysis
- Seventh Demographic and Health Survey (DHS)
- 14 countries of Africa
- Cox proportional risk regression
- Restricted cubic spline
- Interplot interaction model
- Stratified analysis
Main finding
As reported in the abstract
Macrosomia
- Positive association between EHT, PM2.5 and macrosomia
- Macrosomia risk increased with PM2.5 concentration without clear threshold
Observational data: associations, not effects.
Further findings
Exposure window
- EHT and PM2.5 had a higher effect on macrosomia in middle/later and early/middle stages of pregnancy, respectively
Interaction of EHT and PM2.5
- Significant interaction between EHT and PM2.5 on macrosomia
Original publication
Maternal exposure to extreme high‐temperature, particulate air pollution and macrosomia in 14 countries of Africa. Pediatr Obes. Published 21 January 2023. doi:10.
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