Lipids & metabolic liver disease
Lower creatinine to cystatin C ratio is associated with an increased risk of MASLD: A cross‐sectional and prospective study of 368,634 UK Biobank participants
Main finding · MASLD, cross-sectionalResult — go to the resultOdds ratio 1.070 95% CI 1.053–1.088Authors' conclusion
Our results indicated that lower CCR was significantly associated with higher risk of MASLD, based on which predictive models can be developed to screen populations at high risk of developing MASLD.
Study context
- Population
- UK Biobank participants; MASLD per multi-society consensus nomenclature; hepatic steatosis defined as FLI ≥60
- Participants
- 368,634 participants
- Exposure
- Cystatin C ratio (CCR) tertiles
- Outcome
- MASLD (cross-sectional) and onset of MASLD (prospective, excluding baseline MASLD)
Methodological detailsUK Biobank, univariate and multivariate logistic regression
- UK Biobank
- Univariate and multivariate logistic regression
Main finding
MASLD, cross-sectional
Odds ratio
1.070
95% CI 1.053–1.088
P < 0.001
CCR tertile 1
OR 1.070 (95% CI 1.053–1.088); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Onset of MASLD, prospective
| OR (95% CI) | P value | ||
|---|---|---|---|
| CCR tertile 1 | 1.340 (1.077–1.660) | P = 0.009 | |
| CCR tertile 2 | 1.217 (1.021–1.450) | P = 0.029 | |
| 0.512Odds ratio (log scale) |
Onset of MASLD, males
| OR (95% CI) | P value | ||
|---|---|---|---|
| CCR tertile 1 | 1.639 (1.160–2.317) | P = 0.005 | |
| CCR tertile 2 | 1.322 (1.073–1.628) | P = 0.005 | |
| 0.512Odds ratio (log scale) |
- Significant association between CCR and MASLD onset only observed in males
Original publication
Lower creatinine to cystatin C ratio is associated with an increased risk of MASLD: A cross‐sectional and prospective study of 368,634 UK Biobank participants. Clin Endocrinol (Oxf). Published 26 December 2023. doi:10.
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