Longitudinal Trajectory and Early Life Determinant of Childhood Adipokines: Findings From a Racially Diverse Birth Cohort
Authors' conclusion
Our results highlight preterm status, race, and biological sex as predictors of adipokine trajectory throughout childhood. These findings raise the possibility that early life programming of adipokines may contribute to higher metabolic risk in life, especially among Black children born preterm.
Study context
- Population
- Mother-infant pairs in the Boston Birth Cohort, a predominantly Black, indigenous, and people of color study population; leptin and adiponectin measured at birth and in early childhood (mean corrected age 2.18 years [IQR 0.4–10.4])158 preterm
- Participants
- 716 pairs
- Exposure
- Term vs preterm infants
- Pretermn = 158
- Outcome
- Longitudinal trajectories of plasma leptin and adiponectin from birth to early childhood and associated prenatal and infancy factors
- Follow-up
- Birth and early childhood
Methodological detailsracially diverse (predominantly Black, indigenous, and people of color (BIPOC)), longitudinal
- Racially diverse (predominantly BIPOC)
- Longitudinal
Main finding
As reported in the abstract
- Term vs Preterm: P < 0.0001
- Term vs Preterm: P = 0.92
- Term vs Preterm: P < 0.0001
- Term vs Preterm: P = 0.04
Observational data: associations, not effects.
Further findings
Race and childhood adipokines
- Black race associated with higher childhood leptin and lower childhood adiponectin (stepwise regression)
Sex and childhood adipokines
- Female sex associated with higher childhood leptin and lower childhood adiponectin (multivariable regression)
Original publication
Longitudinal Trajectory and Early Life Determinant of Childhood Adipokines: Findings From a Racially Diverse Birth Cohort. J Clin Endocrinol Metab. Published 7 January 2023. doi:10.
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