Liver fibrosis markers and all cause mortality in people with type 2 diabetes: A population based study (The Ayrshire Diabetes Outcomes Cohort (ADOC) Study)
Authors' conclusion
All three fibrosis risk scores were positively associated with all-cause mortality in people with type 2 diabetes, with higher relative risks in younger than older people. Effective interventions are required to minimize excess mortality in people at high risk of liver fibrosis.
Study context
- Population
- People with T2D (ADOC); mean age 65.2 ± 12.1 years, 54.5% men, median diabetes duration 5.8 (2.8–9.3) years; follow-up January 2012 to November 2021
- Participants
- 12,589 people
- Exposure
- High vs low liver fibrosis risk category
- Outcome
- All-cause mortality by liver fibrosis risk category
- Follow-up
- Median 9.8 years
Methodological detailspopulation-based, multivariable Cox regression
- Population-based
- Multivariable Cox regression
Main finding
As reported in the abstract
All-cause mortality, high vs low fibrosis risk
Adjusted hazard ratio (95% CI)
APRI highvs APRI low
3.92(2.88–5.34)
Adjusted HR
- Between FIB4 high and FIB4 low · estimate outside printed CI
- 3.69 (95% CI 1.95–2.75)
- Between NFS high and NFS low · estimate outside printed CI
- 2.32 (95% CI 2.88–4.70)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Liver fibrosis markers and all cause mortality in people with type 2 diabetes: A population based study (The Ayrshire Diabetes Outcomes Cohort (ADOC) Study). Diabetes Obes Metab. Published 13 June 2023. doi:10.
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