Kidney damage predictors in children with metabolically healthy and metabolically unhealthy obesity phenotype
Authors' conclusion
An increased risk of kidney damage has been observed in children with obesity and in particular in those with MUO phenotype. As their role on kidney function, HOMA-IR should be monitored in MUO children and both HOMA-IR and uric acid in MHO children.
Study context
- Population
- Children with obesity (mean age 10.72 ± 2.71 years, BMI-SDS 2.23 ± 0.57) stratified by metabolic phenotype
- Participants
- 396 children
- Exposure
- MUO vs MHO obesity phenotype
- Outcome
- Kidney damage: reduced eGFR (<90 mL/min/1.73m2) and/or albuminuria (≥30 mg/g urinary creatinine)
Main finding
As reported in the abstract
Kidney damage
Odds ratio (95% CI)P value
MUO
1.92(1.22–3.01)
P = 0.005MHO
1.05(1.00–1.09)
P = 0.028- Kidney damage prevalence, study population
- 20.9%
Observational data: associations, not effects.
Further findings
Risk factors for kidney damage in MUO
| OR (95% CI) | P value | ||
|---|---|---|---|
| HOMA-IR (MUO)Only HOMA-IR associated | 2.07 (1.20–3.57) | P = 0.007 | |
| 0.20.5125Odds ratio (log scale) |
Risk factors for kidney damage in MHO
| OR (95% CI) | P value | ||
|---|---|---|---|
| HOMA-IR (MHO)Only significant risk factors in MHO | 1.15 (1.02–1.29) | P = 0.011 | |
| Uric acid (MHO)Only significant risk factors in MHO | 1.15 (1.02–1.30) | P = 0.010 | |
| 0.512Odds ratio (log scale) |
Characteristics of children with vs without kidney damage
- Higher BMI-SDS, homeostasis model assessment of insulin resistance (HOMA-IR), inflammation markers and non-alcoholic fatty liver disease (NAFLD) prevalence with kidney damage (all p < 0.005)
Original publication
Kidney damage predictors in children with metabolically healthy and metabolically unhealthy obesity phenotype. Int J Obes (Lond). Published 9 September 2023. doi:10.
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