Joint association of estimated glucose disposal rate and systemic inflammation response index with mortality in cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study
Authors' conclusion
In CKM syndrome stages 0-3, eGDR and SIRI have joint effect on mortality. Combining these markers can help identify high-risk individuals early, enabling timely monitoring and intervention to improve outcomes.
Study context
- Population
- Participants with Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0–3, National Health and Nutrition Examination Survey (NHANES), 10 cycles 1999–2018
- Participants
- 18,295 participants
- Exposure
- Low estimated glucose disposal rate (eGDR) and high Systemic Inflammation Response Index (SIRI) vs high eGDR and low SIRI
- Outcome
- All-cause mortality
- Follow-up
- Average 121 months
Methodological detailsnationwide, NHANES 1999–2018
- Nationwide
- NHANES 1999–2018
Main finding
As reported in the abstract
Hazard ratio (CI)
Low eGDR + high SIRIvs High eGDR + low SIRI
1.97(1.58–2.44)
eGDR per unit increase
0.90(0.86–0.94)
SIRI per unit increase
1.16(1.11–1.21)
- All-cause deaths
- 1,998
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (CI) | |
|---|---|---|
| CVD mortality · average follow-up 121 monthsLow eGDR + high SIRIvs High eGDR + low SIRI | 2.35 (1.48–3.73) | |
| CVD mortality · average follow-up 121 monthseGDR per unit increase | 0.85 (0.78–0.93) | |
| CVD mortality · average follow-up 121 monthsSIRI per unit increase | 1.33 (1.19–1.46) | |
| 0.20.5125Hazard ratio (log scale) |
- Cardiovascular disease (CVD) mortality — CVD deaths
- 539
Subgroup: age
- Combined impact of eGDR and SIRI particularly significant in patients under 60 years old
Original publication
Joint association of estimated glucose disposal rate and systemic inflammation response index with mortality in cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 29 March 2025. doi:10.
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