Jet-Induced Blood Release From Human Fingertips: A Single-Blind, Randomized, Crossover Trial
Authors' conclusion
Fingertip penetration by jet injection can release a volume of fluid sufficient for blood glucose measurement. Jet injection with a slot-shaped nozzle and/or a nozzle with larger outlet area helps to release more fluid. This technique may enable blood sampling, glucose concentration measurement, and insulin delivery to be performed in a single device.
Study context
- Population
- Healthy volunteers; interventions on four fingertips
- Participants
- 20 healthy volunteers
- Comparison
- Jet injection of saline through three differently shaped and sized nozzles vs lancet prick
- Primary endpoint
- Whether jet injection releases sufficient blood from the fingertip to enable blood glucose measurement
- Follow-up
- Immediately after the intervention
Methodological detailssingle-blind
- Single-blind
Primary result
As reported in the abstract
Blood release sufficient for glucose measurement
- Jet injection released sufficient blood from the fingertip to conduct a glucose measurement
- Slot-shaped nozzle released the most blood, although less than a lancet, with slightly higher pain
Further findings
Accuracy of blood glucose estimated from extracted fluid
- Mean absolute percentage error
- 25%
Safety
Skin reactions · immediately and 24 hours after the intervention
- No consistent evidence that jet injection leads to different skin reactions at the intervention site vs lancet prick
Original publication
Jet-Induced Blood Release From Human Fingertips: A Single-Blind, Randomized, Crossover Trial. J Diabetes Sci Technol. Published 28 October 2021. doi:10.
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