Is trabecular bone score associated with appendicular lean mass?
Authors' conclusion
ALMI was associated with TBS after controlling for age, sex, FMI, and abdominal tissue thickness.
Study context
- Population
- Individuals aged ≥40 years in the Manitoba DXA Registry (February 1999-March 2016); 90% female90% female
- Participants
- 60,196 individuals
- Outcome
- Association between ALMI and TBS
Methodological detailsregistry-based, linear and logistic regression
- Registry-based
- Linear and logistic regression
Main finding
As reported in the abstract
Association of ALMI with TBS
ALMI vs trabecular bone score (TBS), adjusted for age and sex: unstandardized β
0.007
95% CI 0.006 to 0.008; adjusted R2 = 0.130p < 0.001
ALMI vs TBS, adjusted for age, sex, fat mass index (FMI) and abdominal tissue thickness: unstandardized β (95% CI 0.056 to 0.059; adjusted R2 = 0.557; p < 0.001); per 1 kg/m² ALMI, ~half of one population SD or 4.7% of mean TBS
0.058
Observational data: associations, not effects.
Further findings
EWGSOP2 sarcopenia and lowest TBS tertile, adjusted for age, sex and FMI
- OR
- 1.46 (95% CI 1.38 to 1.55)
Descriptive statistics, mean (SD)
- TBS (SD 0.122)
- 1.245
- BMI, kg/m² (SD 4.4)
- 26.4
- ALMI, kg/m² (SD 0.9)
- 6.7
- Lean mass index (LMI), kg/m² (SD 1.7)
- 15.3
- FMI, kg/m² (SD 3.3)
- 10.0
Original publication
Is trabecular bone score associated with appendicular lean mass? Osteoporos Int. Published 8 September 2025. doi:10.
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