Inverse association of insulin-like growth factor binding protein 1 with epicardial and intrathoracic adiposity in older adults: The Longenity study
Authors' conclusion
Circulating IGFBP-1 may be a novel biomarker for visceral adiposity and cardiometabolic risk stratification. Future studies should explore its role in cardiovascular aging.
Study context
- Population
- Older adults from the LonGenity parent study, Albert Einstein Institute of Aging, Bronx NY; non-contrast ECG-gated computed tomography (CT) for fat volume quantification
- Participants
- 102 adults
- Exposure
- Association of serum IGFBP-1 with EAT and intrathoracic adipose tissue (IAT); Of parents with exceptional longevity (OPEL) vs OPUS
- Outcome
- Association of IGFBP-1 with epicardial (EAT) and intrathoracic adipose tissue (IAT)
Main finding
As reported in the abstract
- Higher IGFBP-1 levels significantly associated with lower EAT and IAT, particularly in OPEL
- Inverse relationship remained significant after adjusting for age, BMI, HDL-C and cardiometabolic factors
- In OPUS, point estimates directionally similar but not statistically significant
- Multiple linear regression adjusted for demographic, clinical and laboratory factors
Observational data: associations, not effects.
Original publication
Inverse association of insulin-like growth factor binding protein 1 with epicardial and intrathoracic adiposity in older adults: The Longenity study. Diabetes Res Clin Pract. Published 11 January 2026. doi:10.
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