Intravenous Oxytocin Does Not Affect Glucose‐Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men
Authors' conclusion
Acute intravenous oxytocin infusion resulting in supraphysiological plasma concentrations did not modulate pancreatic or gut hormone secretion, or markers of bone turnover during a controlled, stepwise glucose challenge in healthy men
Study context
- Population
- Healthy men (age 24.9 ± 3.2 years; BMI 23.8 ± 1.5 kg/m²), 3-hour IV graded glucose infusion (2–12 mg/kg/min) on three separate dayscrossover
- Participants
- 20 men
- Comparison
- IV oxytocin 0.1 or 0.2 IU/min vs placebo during graded glucose infusion
- Primary endpoint
- Baseline-subtracted AUC for C-peptide concentrations
Methodological detailsplacebo-controlled, double-blind, crossover
- Placebo-controlled
- Double-blind
- Crossover
Primary result
As reported in the abstract
C-peptide response (baseline-subtracted AUC)
- Neither oxytocin dose affected C-peptide response vs placebo
Secondary outcomes
Plasma glucose, glucagon, GIP, GLP-1, CTX, P1NP and triglycerides
- Circulating concentrations of plasma glucose, C-peptide, glucagon, GIP, GLP-1, CTX, P1NP and triglyceride were similar across study visits; neither oxytocin dose affected any secondary metabolic outcome vs placebo
Peak plasma oxytocin concentrations
- Peak plasma oxytocin concentration (mean ± SD as printed)
- 193 ± 29 pg/mL
- Peak plasma oxytocin concentration (mean ± SD as printed)
- 401 ± 66 pg/mL
- The abstract does not print which dose each value belongs to
Original publication
Intravenous Oxytocin Does Not Affect Glucose‐Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men. Diabetes Obes Metab. Published 3 September 2026. doi:10.
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