Insulin-like growth factor-I and symptoms of acromegaly according to time since somatostatin receptor ligand injection
Authors' conclusion
IGF-I concentrations increased according to time since SRL injection. Patient-reported outcomes fluctuated, correlating with IGF-I and sαKL changes. Measuring IGF-I at the end of the injection cycle is advisable. Decreases in SRL concentration suggest phase-based differences in IGF-I concentrations. These findings inform personalized approaches to acromegaly, with titration of therapy based on individual IGF-I and/or PROMs fluctuation.
Study context
- Population
- Patients with acromegaly receiving monthly long-acting somatostatin receptor ligands (SRLs)
- Participants
- 20 patients
- Exposure
- Late vs early phase of the SRL injection cycle
- Outcome
- IGF-I concentration (LC-MS and IDS-iSYS)
- Follow-up
- Cycle 2
Methodological details2 monthly injection cycles, early (week 1) vs late (week 4) phase sampling, IGF-I by LC-MS and IDS-iSYS immunoassay
- 2 monthly injection cycles
- Early (week 1) vs late (week 4) phase sampling
- IGF-I by LC-MS and IDS-iSYS immunoassay
Main finding
As reported in the abstract
- Late phase vs Early phase: P = 0.045
- Late phase vs Early phase: P = 0.023
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| SRL concentrationLower in late phase | P = 0.008 |
PASQ score · cycle 1
- PASQ score week 4 (worse)
- 18.10 ± 11.96
- PASQ score week 2; P vs week 4
- 15.53 ± 9.94; P = .011
- PASQ score week 3; P vs week 4
- 15.00 ± 12.49; P = .021
Correlations of changes (Δ)
- ΔSRL vs ΔIGF-I IDS-iSYS
- r = −0.385, P = .047
- ΔsαKL vs ΔPASQ score
- r = 0.337, P = .034
- ΔsαKL vs swelling
- r = 0.335, P = .035
- ΔACROQoL physical significantly correlated with ΔIGF-I
Original publication
Insulin-like growth factor-I and symptoms of acromegaly according to time since somatostatin receptor ligand injection. Eur J Endocrinol. Published 26 September 2025. doi:10.
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