Increased epicardial adipose tissue is associated with left ventricular reverse remodeling in dilated cardiomyopathy
Authors' conclusion
In DCM patients, the CMR-derived EAT parameters increased after 1-2 years of GDMT and significantly correlated with improved ventricular structure and function, independent of changes in BMI and abdominal adiposity, which may indicate the potential protective role of EAT in DCM patients.
Study context
- Population
- Patients with dilated cardiomyopathy (DCM) with baseline and follow-up cardiac magnetic resonance (CMR) after 1–2 years of guideline-directed medical therapy (GDMT); mean age 45.7 ± 15.1 years, 157 male
- Participants
- 232 patients
- Exposure
- Changes in epicardial adipose tissue (EAT) parameters in patients with vs without left ventricular reverse remodeling (LVRR)
- Outcome
- Association of changes in EAT (pericardial and epicardial fat thickness, paracardial fat volume) and abdominal adiposity with presence of LVRR
- Follow-up
- Median 15.5 months (IQR 12.5-19.1 months) of GDMT
Methodological detailsconsecutive enrolment, baseline and follow-up CMR
- Consecutive enrolment
- Baseline and follow-up CMR
Main finding
As reported in the abstract
Association of EAT increment with LVRR (adjusted for age, sex, delta BMI) · median 15.5 months
Increment of pericardial fat thickness, OR
1.53
95% CI 1.27 to 1.83p < 0.001
Increment of epicardial fat thickness, OR
2.10
95% CI 1.68 to 2.63p < 0.001
Increment of paracardial fat volume, OR
1.01
95% CI 1.01 to 1.02p = 0.001
Observational data: associations, not effects.
Original publication
Increased epicardial adipose tissue is associated with left ventricular reverse remodeling in dilated cardiomyopathy. Cardiovasc Diabetol. Published 18 December 2024. doi:10.
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