Improved glycaemic control induced by evening activity breaks does not persist overnight amongst healthy adults: A randomized crossover trial
Authors' conclusion
Performing activity breaks in the evening results in acute reductions in interstitial glucose concentrations; however, the magnitude of these changes is not maintained overnight or into the following 48 hours.
Study context
- Population
- Healthy adults; female n = 20, mean ± SD age 25.5 ± 5.6 years, BMI 29.2 ± 6.9 kg/m²provided data for analysis
- Participants
- 28 adults
- Comparison
- Regular activity breaks vs prolonged sitting for 4 h in the evening
- Primary endpoint
- Free-living interstitial glucose levels (CGM)
- Follow-up
- 48-h after intervention
Methodological detailslaboratory-based interventions
- Laboratory-based interventions
Primary result
As reported in the abstract
during the 4-h intervention
RABs vs SITDifference in mean interstitial glucose, mmol/L/4 h (95% CI)P value
Lowered by 8.3%
−0.47(−0.74 to −0.20)
P = 0.001- Lowered by 8.9%
- difference in AUC −2.01 mmol/L/4 h (95% CI −3.05 to −0.97); P < 0.001
Further findings
| Outcome | Difference (mmol/L) (95% CI) | P value | |
|---|---|---|---|
| Continuous overall net action of glucose at 1 h (CONGA-1) · first nocturnal periodIncreased by 22% | 0.18 (0.03–0.29) | P = 0.018 | |
| Continuous overall net action of glucose at 1 h (CONGA-1) · 24-h post interventionIncreased by 10% | 0.09 (0.01–0.17) | P = 0.025 | |
| −0.200.20.4Difference, mmol/L (linear scale) |
| Outcome | Percentage increase (95% CI) | P value | |
|---|---|---|---|
| SD glucose · first nocturnal period | 26% (4.9–42.7) | P = 0.019 | |
| SD glucose · 24-h post intervention | 15% (6.6–22.4) | P = 0.001 | |
| −200204060Difference (linear scale) |
Mean glucose and AUC · first nocturnal period and 24-h post intervention
- No significant differences in mean glucose and AUC between conditions
Original publication
Improved glycaemic control induced by evening activity breaks does not persist overnight amongst healthy adults: A randomized crossover trial. Diabetes Obes Metab. Published 4 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →