Impaired muscle parameters in adults with mild to severe types of osteogenesis imperfecta: a cross-sectional study
Authors' conclusion
To conclude, adults with OI present with markedly impaired muscle function which may partially be explained by their altered body composition.
Study context
- Population
- Adults with mild to severe types of OI (n=68; mean age 42.2 yr; 27 men) and healthy age- and sex-matched controls68 OI, 68 controls
- Exposure
- Adults with OI vs healthy controls
- Controlsn = 68reference
- Outcome
- Muscle function (isometric force, endurance, functional lower limb strength) and body composition vs controls
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
Isometric, endurance and functional muscle strength vs controls
MD
19-43%
OI type I · lower with OI type I
MD
25-68%
OI type IV/V · lower with OI type IV/V
MD
20-72%
OI type III · lower with OI type III
Observational data: associations, not effects.
Further findings
Dynamic muscle function and body composition, OI type I vs controls (sub cohort)
- Lower peak force with OI type I (MD)
- 25-29%
- Lower peak power with OI type I (MD)
- 18-60%
- Lower lean mass with OI type I (MD)
- 10-17%
- Lower muscle cross-sectional area (CSA) with OI type I (MD)
- 9-21%
- Lower muscle density with OI type I (MD)
- 2-3%
- Higher adiposity indices with OI type I (MD)
- 24-42%
Differences between OI types
- Functional lower limb strength and maximal muscle force significantly different between OI types; muscle endurance was not
Original publication
Impaired muscle parameters in adults with mild to severe types of osteogenesis imperfecta: a cross-sectional study. J Bone Miner Res. Published 10 January 2024. doi:10.
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