Impact of Sleeve Gastrectomy Versus Intensive Lifestyle Modifications With Obesity Management Medications on BMI Trajectory and Target Attainment: A Prospective Matched Cohort Study
Authors' conclusion
SG was associated with greater and more rapid weight loss than ILM/OMM over 1 year, with earlier achievement of ≥ 25% TWL.
Study context
- Population
- Adults with severe obesity (BMI ≥ 35 kg/m², obesity-related comorbidities)matched cohort, 1:1
- Participants
- 190 adults
- Exposure
- Sleeve gastrectomy (SG) vs intensive lifestyle modification with obesity management medications (ILM/OMM)
- Outcome
- Change in BMI and time to achieving ≥ 25% total weight loss (TWL)
- Follow-up
- 12 months
Methodological detailsmatched 1:1 for age, sex, BMI and diabetes duration, real-world clinical setting
- Matched 1:1 for age, sex, BMI and diabetes duration
- Real-world clinical setting
Main finding
As reported in the abstract
Model-based BMI
SG vs ILM/OMMBetween-group difference, kg/m2 (95% CI)P value
Model-based BMI
−3.2(−4.9 to −1.5)
P < 0.001SG vs ILM/OMMHazard ratio (time to ≥ 25% TWL) (95% CI)P value
Median time 6 months with SG; not reached by 12 months with ILM/OMM
13.85(7.81–24.58)
log-rank p < 0.001Observational data: associations, not effects.
Secondary outcomes
| Outcome | SG | ILM/OMM | Difference (percentage points) (95% CI) | P value | |
|---|---|---|---|---|---|
| Estimated %TWL · 12 months | 37.6% (95% CI 36.5–38.7) | 18.0% (95% CI 16.9–19.1) | 19.6 (18.1–21.1) | P < 0.001 | |
| −100102030Difference, percentage points (linear scale) |
Metabolic outcomes
- Both groups showed metabolic improvement, although between-group differences were limited
Original publication
Impact of Sleeve Gastrectomy Versus Intensive Lifestyle Modifications With Obesity Management Medications on BMI Trajectory and Target Attainment: A Prospective Matched Cohort Study. Diabetes Obes Metab. Published 31 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →