Impact of Type 2 Diabetes on the Outcomes of Solid Organ Transplantations in the U.S.: Data From a National Registry
Authors' conclusion
The prevalence of T2D in solid organ transplantation candidates is increasing. In all solid organ transplantations, pretransplantation T2D was independently associated with higher posttransplantation mortality, most profoundly in kidney transplantations.
Study context
- Population
- Adults aged ≥18 years who received a lung, heart, liver or kidney transplant in the U.S., 2006–2021
- Participants
- 462,692 solid organ transplant recipients
- Exposure
- Pretransplantation T2D vs no T2D
- Outcome
- Posttransplantation mortality
Methodological detailsnational registry, Scientific Registry of Transplant Recipients 2006–2021
- National registry
- Scientific Registry of Transplant Recipients 2006–2021
Main finding
As reported in the abstract
Posttransplantation mortality, adjusted
Each group vs without T2DEstimate (95% CI)P value
T2D
aHR (lung) 1.08(1.03–1.13)
P < 0.01T2D
aHR (heart) 1.26(1.20–1.32)
P < 0.01T2D
aHR (liver) 1.25(1.21–1.28)
P < 0.01T2D
aHR (kidney) 1.65(1.62–1.68)
P < 0.01Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Posttransplantation mortality, lung | P < 0.01 |
| Posttransplantation mortality, heart | P < 0.0001 |
| Posttransplantation mortality, liver | P < 0.0001 |
| Posttransplantation mortality, kidney | P < 0.0001 |
- Posttransplantation mortality, lung — 3 years, T2D vs without
- 32.1% vs. 29.3%
- Posttransplantation mortality, lung — 5 years, T2D vs without
- 46.4% vs. 42.6%
- Posttransplantation mortality, heart — 1 year, T2D vs without
- 11.2% vs. 9.1%
- Posttransplantation mortality, heart — 5 years, T2D vs without
- 24.4% vs. 20.6%
- Posttransplantation mortality, liver — 1 year, T2D vs without
- 10.6% vs. 8.9%
- Posttransplantation mortality, liver — 5 years, T2D vs without
- 26.2% vs. 22.0%
- Posttransplantation mortality, kidney — 1 year, T2D vs without
- 5.3% vs. 2.5%
- Posttransplantation mortality, kidney — 5 years, T2D vs without
- 20.8% vs. 10.1%
Prevalence of pretransplantation T2D
- Lung
- 15%
- Heart
- 26%
- Liver
- 25%
- Kidney
- 30%
- Trend
- increasing over time
Original publication
Impact of Type 2 Diabetes on the Outcomes of Solid Organ Transplantations in the U.S.: Data From a National Registry. Diabetes Care. Published 25 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →