Impact of systemic treatments for advanced thyroid cancer on the adrenal cortex
Authors' conclusion
Our data confirm that systemic treatments for advanced thyroid cancer can lead to impaired cortisol secretion. A reduction in the other hormones secreted by the adrenal cortex has been first reported and should be considered in the more appropriate management of these fragile patients.
Study context
- Population
- Patients on systemic treatments for advanced thyroid cancerACTH stimulation tests in 26
- Participants
- 36 patients
- Exposure
- Lenvatinib vs Vandetanib vs Selpercatinib
- Lenvatinibn = 25
- Vandetanibn = six
- Selpercatinibn = five
- Outcome
- Entire adrenal function: ACTH, cortisol and all adrenal hormones
- Follow-up
- Monthly
Methodological detailsmonthly hormonal evaluation
- Monthly hormonal evaluation
Main finding
As reported in the abstract
Adrenal function · median treatment period of 7 months
Increase in ACTH values
80-100% of patients
Impaired cortisol response to ACTH test
19% of cases
Observational data: associations, not effects.
Further findings
Fatigue improvement with cortisone acetate replacement in patients with primary adrenal insufficiency (PAI)
- Fatigue improved
- 14/17 (82%)
Original publication
Impact of systemic treatments for advanced thyroid cancer on the adrenal cortex. Eur Thyroid J. Published 9 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →