Higher Serum Testosterone Protects Against the Development of Type 2 Diabetes in Middle‐Aged but Not Older Men
Main finding · 5-year incident T2D per serum testosterone concentrationResult — go to the resultOdds ratio 0.92 95% CI 0.87–0.97Authors' conclusion
These data suggest that higher concentrations of serum testosterone are protective against incident T2D in younger but not older men.
Study context
- Population
- Men without T2D, cancer or testosterone treatment, with baseline and 5-year follow-up assessments in the Men Androgen Inflammation Lifestyle and Environment Study cohort109 incident T2D cases
- Participants
- 1,299 men
- Exposure
- Baseline serum testosterone and 5-year incident T2D
- Outcome
- Incident T2D
- Follow-up
- 5 years
Methodological detailsconfounder-adjusted logistic regression, restricted cubic splines, complete case analysis, multiple imputation sensitivity analysis
- Confounder-adjusted logistic regression
- Restricted cubic splines
- Complete case analysis
- Multiple imputation sensitivity analysis
Main finding
As reported in the abstract
5-year incident T2D per serum testosterone concentration
Odds ratio
0.92
95% CI 0.87–0.97
P = 0.001
Serum testosterone
OR 0.92 (95% CI 0.87–0.97); P = 0.001
Per serum testosterone concentration, as printed
- 5-year incident T2D
- 109 cases (8.4%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Interaction of testosterone with WCNo detectable interaction | P = 0.93 |
| Interaction of testosterone with baseline A1cNo detectable interaction | P = 0.38 |
| Interaction of testosterone with ageStrong interaction | P = 0.003 |
Interaction of testosterone with age
- Low testosterone associated with elevated T2D risk only in younger men
Original publication
Higher Serum Testosterone Protects Against the Development of Type 2 Diabetes in Middle‐Aged but Not Older Men. Diabetes Obes Metab. Published 25 May 2026. doi:10.
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