Hepatocellular carcinoma in a large cohort of type 2 diabetes patients
Authors' conclusion
Incidence of HCC in DM2 is more than tripled compared to the general population with high mortality. These figures are higher than those expected from the previous evidence. In parallel with known risk factors for liver disease, such as viruses and alcohol, insulin-resistance characteristics are associated with a higher probability of HCC.
Study context
- Population
- T2D and general population, regional administrative and hospital databases, 2009–2019902 hepatocellular carcinoma (HCC)
- Participants
- 137,158 participants
- Exposure
- T2D population vs general population
- Outcome
- Incidence of HCC
- Follow-up
- 2009–2019
Methodological detailsregional administrative and hospital databases, follow-up study
- Regional administrative and hospital databases
- Follow-up study
Main finding
As reported in the abstract
HCC incidence
DM2
8.05 cases per 10,000 yearly
Observational data: associations, not effects.
Further findings
Survival of HCC patients
- Survival of HCC patients vs cancer-free diabetic controls
- 1/3
Determinants of HCC
- Age, male sex, alcohol abuse, previous viral hepatitis B and C, cirrhosis, low platelet count, elevated GGT/ALT, higher BMI and HbA1c associated with HCC occurrence
- Diabetes therapy not adversely associated with HCC development
Original publication
Hepatocellular carcinoma in a large cohort of type 2 diabetes patients. Diabetes Res Clin Pract. Published 24 April 2023. doi:10.
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