Healthcare Resource Use Associated With Tumor-Induced Osteomalacia: A Literature Review
Authors' conclusion
TIO is associated with a substantial healthcare resource burden. Improvements in the diagnostic process could lead to better management of TIO, thereby benefiting patients and reducing that burden.
Study context
- Population
- Published patients with tumor-induced osteomalacia (TIO), an ultra-rare paraneoplastic syndrome caused by FGF23-secreting tumors414 publications · 376 case reports
- Participants
- 621 patients
- Outcome
- Healthcare resource use and disease characteristics in TIO
Main finding
As reported in the abstract
Disease characteristics and healthcare resource use (case-report patients)
- Age, mean (SD)
- 46.3 (15.8) years
- Male
- 57.6%
- Time from first symptoms to diagnosis, mean (SD)
- 4.6 (4.7) years
- Imaging procedures per patient, mean (SD), where reported
- 4.1 (2.7)
- Tumor resection attempted
- 81.0%
- Tumor resection successful
- 67.0%
- Fracture reported
- 49.3%
Further findings
Association analyses
- Longer time to diagnosis associated with poorer tumor resection outcomes and higher probability of tumor recurrence
- Unfavorable tumor resection outcomes associated with greater use of pharmacologic treatment and greater likelihood of orthopedic surgery
Original publication
Healthcare Resource Use Associated With Tumor-Induced Osteomalacia: A Literature Review. J Clin Endocrinol Metab. Published 24 June 2024. doi:10.
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