Growth Kinetics of Bilateral Macronodular Adrenocortical Disease: Long-Term Imaging Follow-Up in Natural and Surgical Cohorts
Authors' conclusion
BMAD exhibits exponential growth despite variability in size and growth speed, which supports using VDT and SGR for the individualized growth assessment and imaging follow-up. Postoperative adrenal volume may help assess autonomous cortisol secretion status after unilateral adrenalectomy.
Study context
- Population
- Bilateral macronodular adrenocortical disease (BMAD) patients with ≥2 CT scans
- Participants
- 52 vs 23
- Exposure
- Natural course vs Post-unilateral adrenalectomy
- Natural coursen = 52
- Post-unilateral adrenalectomyn = 23
- Outcome
- Natural growth and post-unilateral total adrenalectomy changes of adrenal volume
Methodological detailslinear mixed-effects model
- Linear mixed-effects model
Main finding
As reported in the abstract
Median volume doubling time (VDT), natural course; range 1.72-102.70
11.82 years
Median specific growth rate (SGR), natural course; range 0.67% to 40.41%
5.87%/year
Observational data: associations, not effects.
Further findings
Total adrenal volume, natural course
- Total adrenal volume range
- 5.5 to 92.8 mL
- Left adrenal volume significantly larger than right; males greater volumes than females
- P < 0.001
Postoperative contralateral adrenal volume for diagnosing autonomous cortisol secretion
- AUC
- 0.913 (95% CI 0.813-1.000)
Original publication
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