Glucocorticoid reduction after starting crinecerfont in pediatric patients with classic congenital adrenal hyperplasia: practical perspectives
Methodological detailsexpert panel, 11 expert endocrinologists in a panel (December 2024); a smaller panel reconvened in January 2025 to develop recommendations
- Expert panel
- 11 expert endocrinologists in a panel (December 2024); a smaller panel reconvened in January 2025 to develop recommendations
Recommendations
As issued by the authors
Tailor glucocorticoid (GC) reduction to individual clinical goals, cortisol needs and lifestyle
Guide GC dose reductions by androgen concentrations, aiming to keep androgens near normal range to achieve normal growth and normalize bone age maturation while minimizing complications of long-term GC exposure
Reduce GC doses gradually with frequent monitoring, never below the dose needed for physiologic cortisol replacement
Original publication
Glucocorticoid reduction after starting crinecerfont in pediatric patients with classic congenital adrenal hyperplasia: practical perspectives. J Clin Endocrinol Metab. Published 4 May 2026. doi:10.
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