Glucagonoma and Glucagonoma Syndrome: An Updated Review
Authors' conclusion
Glucagonoma is a rare pathology, with peculiar characteristics that need to be acknowledged to achieve a timely diagnosis and finally improve patient prognosis.
Study context
- Population
- Published cases of glucagonomathree case series
- Participants
- 86 / 216 / 407
- Comparison
- Cases reported in and after 2017 vs earlier series
- Current reviewn = 86
- Songn = 216
- Soga and Yakuwan = 407
- Outcome
- Clinical features of glucagonoma, cases 2017 onwards
Methodological detailscomparison of three periods
- Comparison of three periods
Main finding
As reported in the abstract
- Males / females
- 40 / 46
- Average age
- 48.2 years
- Male-to-female ratio
- 0.87
- NME
- 93.2% (69/74)
- DM
- 70.3% (50/74)
- Weight loss
- 62.2% (46/74)
- Anaemia
- 44.6% (33/74)
- Glossitis or stomatitis or cheilitis
- 31.1% (23/74)
- Tumour in pancreatic tail, of 85 pancreatic cases
- 38.8%
- Average tumour size
- 4.6 cm
- Metastasis
- 52.3% (45/86)
Further findings
Comparison with previous series
- Earlier age at diagnosis and higher rate of NME vs previous series, consistent with higher diagnostic accuracy
Original publication
Glucagonoma and Glucagonoma Syndrome: An Updated Review. Clin Endocrinol (Oxf). Published 4 July 2025. doi:10.
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