GLP ‐1 Receptor Agonists and Psychiatric Outcomes in Adolescents: A Systematic Review and Meta‐Analysis
Pooled result · Suicidal ideationResult — go to the resultRelative risk 0.73 95% CI 0.54–0.99Authors' conclusion
GLP-1 RAs were not associated with higher rates of suicidal behaviour or depression in adolescents. Pooled analysis suggested a possible lower risk of suicidal ideation, although this finding should be interpreted cautiously.
Study context
- Population
- Adolescents treated for overweight, obesity or T2D11 studies (9 randomized controlled trials (RCTs), 2 observational)
- Participants
- 10,175 adolescents
- Comparison
- GLP-1 RAs vs placebo, no treatment or standard of care
- Outcome
- Suicidal ideation
Methodological detailsPRISMA 2020, GRADE certainty assessment, sensitivity and subgroup analyses
- PRISMA 2020
- GRADE certainty assessment
- Sensitivity and subgroup analyses
Pooled result
As reported in the abstract
Relative risk
0.73
95% CI 0.54–0.99
P = 0.046
GLP-1 RAsvs Control
RR 0.73 (95% CI 0.54–0.99); P = 0.046
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Suicide attemptsI 2 = 0% | 0.66 (0.16–2.61) | P = 0.444 | |
| Depressive symptomsI 2 = 50.4% | 0.73 (0.36–1.48) | P = 0.282 | |
| 0.10.31310Relative risk (log scale) |
Original publication
GLP ‐1 Receptor Agonists and Psychiatric Outcomes in Adolescents: A Systematic Review and Meta‐Analysis. Diabetes Obes Metab. Published 11 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →