Osteoporosis, bone & mineral

Global Epidemiology of Hip Fractures: Secular Trends in Incidence Rate, Post‐Fracture Treatment, and All‐Cause Mortality

J Bone Miner ResPublished Multinational cohort study

Authors' conclusion

Substantial variations exist in the global epidemiology of hip fractures and postfracture outcomes.

Study context

Population
Patients aged ≥50 years hospitalized with a hip fracture, 2005–2018, 19 countries and regionship fractures, 20 databases
Participants
4,115,046 patients
Outcome
Age- and sex-standardized incidence rates of hip fractures; post-hip fracture anti-osteoporosis treatment; all-cause mortality after hip fracture
Methodological detailspatient-level healthcare data, standardized protocol and common data model, 19 countries and regions, 20 databases
  • Patient-level healthcare data
  • Standardized protocol and common data model
  • 19 countries and regions
  • 20 databases

Main finding

As reported in the abstract

Age- and sex-standardized hip fracture incidence per 100,000 population

Lowest incidence: Brazil

95.1

95% CI 94.8–95.4

Highest incidence: Denmark

315.9

95% CI 314.0–317.7

Observational data: associations, not effects.

Further findings

Projected annual number of hip fractures · 2018 to 2050

Estimated total annual number nearly doubled from 2018 to 2050

Post-hip fracture anti-osteoporosis treatment · within 1 year

Lowest: Germany
11.5% (95% CI 11.1% to 11.9%)
Highest: UK
50.3% (95% CI 50.0% to 50.7%)

All-cause mortality · within 1 year

Lowest: Singapore
14.4% (95% CI 14.0% to 14.8%)
Highest: UK
28.3% (95% CI 28.0% to 28.6%)

Sex differences

Males had lower anti-osteoporosis medication use than females, higher all-cause mortality, and a larger increase in projected hip fractures by 2050

Original publication

Global Epidemiology of Hip Fractures: Secular Trends in Incidence Rate, Post‐Fracture Treatment, and All‐Cause Mortality. J Bone Miner Res. Published 29 May 2023. doi:10.1002/jbmr.4821

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