Germline Telomere-Regulating Gene Variants Are Not Associated with Thyroid Cancer in a Saudi Arabian Population
Authors' conclusion
Unlike the recently reported results from the United States, TRG variants do not seem to play a role in sporadic or familial TC samples from the Saudi Arabian population.
Study context
- Population
- Patients with sporadic or familial thyroid cancer, tertiary care hospital in Saudi Arabia26 families
- Participants
- 189 vs 63
- Exposure
- Sporadic thyroid cancer (TC) vs Familial TC
- Sporadic TCn = 189
- Familial TCn = 63
- Outcome
- Germline telomere-regulating gene (TRG) variants on whole exome sequencing of peripheral blood DNA
Methodological detailssingle tertiary care hospital, whole exome sequencing
- Single tertiary care hospital
- Whole exome sequencing
Main finding
As reported in the abstract
TRG variants
| Group | Value | Telomere-regulating genes (TRG) variants found |
|---|---|---|
| Sporadic TC | 20.6% | 8 |
Sporadic TC
Value20.6%
Telomere-regulating genes (TRG) variants found8
- Sporadic TC: ACD variants (3) in patients
- 30
- Sporadic TC: TERF1 variants (2) in patients
- 4
- Sporadic TC: TERT variants (3) in patients
- 5
Observational data: associations, not effects.
Original publication
Germline Telomere-Regulating Gene Variants Are Not Associated with Thyroid Cancer in a Saudi Arabian Population. Thyroid. Published 28 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →