Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study
Authors' conclusion
Associations were found between genetic liability to type 2 diabetes and an increased risk of a broad range of GDs, highlighting the importance of GD prevention in patients with type 2 diabetes.
Study context
- Population
- Genetic association data for 23 common gastrointestinal diseases from FinnGen, UK Biobank and other large consortia
- Comparison
- Genetic liability to T2D and glycemic traits vs risk of 23 common gastrointestinal diseases
- Outcome
- Risk of 23 common gastrointestinal diseases
Methodological detailsgenetic variants as instrument variables, FinnGen, UK Biobank and other large consortia, Instruments: uncorrelated genome-wide significant variants for T2D (n = 231), fasting insulin (n = 38), fasting glucose (n = 71), HbA1c (n = 75)
- Genetic variants as instrument variables
- FinnGen, UK Biobank and other large consortia
- Instruments: uncorrelated genome-wide significant variants for T2D (n = 231), fasting insulin (n = 38), fasting glucose (n = 71), HbA1c (n = 75)
Main finding
As reported in the abstract
GD risk per 1-unit increase in log-transformed OR of T2D
- Genetic liability to T2D associated with risk of gastrointestinal diseases (GDs)
- 12 GDs
- OR, gastroesophageal reflux disease
- 1.06 (95% CI, 1.03-1.09)
- OR, gastric ulcer
- 1.12 (95% CI, 1.07-1.17)
- OR, acute gastritis
- 1.11 (95% CI, 1.03-1.20)
- OR, chronic gastritis
- 1.07 (95% CI, 1.01-1.13)
- OR, irritable bowel syndrome
- 1.08 (95% CI, 1.03-1.12)
- OR, diverticular disease
- 1.04 (95% CI, 1.01-1.07)
- OR, acute pancreatitis
- 1.08 (95% CI, 1.02-1.14)
- OR, cholelithiasis
- 1.09 (95% CI, 1.05-1.12)
- OR, cholelithiasis with cholecystitis
- 1.09 (95% CI, 1.05-1.13)
- OR, NAFLD
- 1.29 (95% CI, 1.17-1.43)
- OR, liver cirrhosis
- 1.12 (95% CI, 1.03-1.21)
- OR, ulcerative colitis
- 0.93 (95% CI, 0.89-0.97)
Further findings
Genetically predicted higher fasting insulin and fasting glucose and GDs
- Higher fasting insulin: GDs associated
- six
- Higher fasting glucose: GDs associated
- one
Original publication
Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study. Diabetes Care. Published 17 February 2023. doi:10.
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