External validation and calibration of risk equations for prediction of diabetic kidney diseases among patients with type 2 diabetes in Taiwan
Authors' conclusion
Risk equations for prediction of DKD progression in real-world Taiwanese T2D patients were established, which can be incorporated into a multi-state simulation model to project and differentiate individual DKD risks for supporting timely interventions and health economic research.
Study context
- Population
- Real-world patients with T2D in Taiwan
- Comparison
- Risk equations from UKPDS-OM2, RECODe and CHIME models
- Outcome
- Discrimination (AUROC) and calibration (calibration slope and intercept, Greenwood-Nam-D'Agostino (GND) test) of risk equations for diabetic kidney disease (DKD) progression (microalbuminuria, macroalbuminuria, renal failure)
Methodological detailsreal-world population, recalibration of baseline hazards
- Real-world population
- Recalibration of baseline hazards
Performance
As reported in the abstract
| Test or model | AUROC, microalbuminuria | AUROC, macroalbuminuria | AUROC, renal failure |
|---|---|---|---|
| RECODe | 0.62 | 0.76 | 0.64 |
| CHIME | — not stated in the abstract | — not stated in the abstract | 0.77 |
| UKPDS-OM2 | — not stated in the abstract | — not stated in the abstract | 0.60 |
AUROC, microalbuminuria
RECODe0.62
CHIME— not stated in the abstract
UKPDS-OM2— not stated in the abstract
AUROC, macroalbuminuria
RECODe0.76
CHIME— not stated in the abstract
UKPDS-OM2— not stated in the abstract
AUROC, renal failure
RECODe0.64
CHIME0.77
UKPDS-OM20.60
— not stated in the abstract
Further findings
| Outcome | RECODe | CHIME |
|---|---|---|
| Calibration slope/intercept after recalibration | ||
| Slope/intercept, microalbuminuria | 0.87/0.0459 | — not stated in the abstract |
| Slope/intercept, macroalbuminuria | 1.10/0.0004 | — not stated in the abstract |
| Slope/intercept, renal failure | — not stated in the abstract | 0.95/−0.0014 |
— not stated in the abstract
Calibration slope/intercept after recalibration
- Calibration improved after recalibration
Original publication
External validation and calibration of risk equations for prediction of diabetic kidney diseases among patients with type 2 diabetes in Taiwan. Cardiovasc Diabetol. Published 9 October 2024. doi:10.
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