Evaluating biased agonism of glucagon‐like peptide‐1 ( GLP ‐1) receptors to improve cellular bioenergetics: A systematic review
Authors' conclusion
GLP-1 receptor biased agonism may be associated with greater weight-lowering and glucose-lowering effects as well as improved safety and tolerability.
Study context
- Population
- Primary studies reporting effects of biased GLP-1 RAs on cellular signal transduction and bioenergetic outcomes; PubMed, Ovid and Scopus, inception to April 2025
- Comparison
- Biased GLP-1 RAs vs non-biased GLP-1 RAs
- Outcome
- Cellular signalling and bioenergetic outcomes
Pooled result
As reported in the abstract
- GLP-1 receptor biased agonism contributes to improved bioenergetic outcomes
- Biased agonism associated with increased cAMP production and accumulation
- Biased agonism associated with increased ERK1/2 phosphorylation
- Biased agonism associated with decreased GLP-1 receptor internalisation and recycling
- Improved glucose control and insulin response observed
Original publication
Evaluating biased agonism of glucagon‐like peptide‐1 ( GLP ‐1) receptors to improve cellular bioenergetics: A systematic review. Diabetes Obes Metab. Published 29 July 2025. doi:10.
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