Epidemiology and Natural History of Preclinical and Clinical Obesity: Insights From a UK Cohort
Authors' conclusion
In a large UK cohort, preclinical and clinical obesity were common, but the risk for incident CVD was elevated for those with clinical obesity.
Study context
- Population
- Adults enrolled in the UK Biobank
- Participants
- 502,233 adults
- Exposure
- Preclinical obesity vs clinical obesity
- Outcome
- Prevalence
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Distribution of clinical obesity
- Clinical obesity more prevalent in men, elderly, South Asians, and lower education or income level groups
Incident cardiovascular disease (CVD) in those without baseline CVD
- Clinical obesity associated with increased hazard of incident stroke, HF and MI
Original publication
Epidemiology and Natural History of Preclinical and Clinical Obesity: Insights From a UK Cohort. Obesity (Silver Spring). Published 20 January 2026. doi:10.
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