Epicardial adipose tissue volume is associated with impaired left ventricular strain in patients with metabolic syndrome: the mediating role of myocardial energetic efficiency
Authors' conclusion
In patients with metabolic syndrome, increased EATV was independently associated with impaired LV myocardial strain, with reduced MEEI partly explaining the observed EATV-LV dysfunction association.
Study context
- Population
- Patients with metabolic syndrome and age- and sex-matched controls undergoing cardiac magnetic resonance (CMR)
- Participants
- 225 vs 68
- Exposure
- Metabolic syndrome (MetS) patients vs matched controls; association of epicardial adipose tissue volume (EATV) with left ventricular (LV) strain mediated by myocardial energetic efficiency index (MEEI)
- MetSn = 225
- Controlsn = 68reference
- Outcome
- Direct and MEEI-mediated effects of EATV on LV myocardial strain
Methodological detailsage- and sex-matched controls, cardiac magnetic resonance, mediation analysis
- Age- and sex-matched controls
- Cardiac magnetic resonance
- Mediation analysis
Main finding
As reported in the abstract
EATV, MEEI and LV myocardial strain
- EATV correlation with MEEI
- r = - 0.224, P < 0.001
- EATV correlation with LV peak strain in all three directions
- r = - 0.174 to - 0.332, P < 0.01
- EATV independent predictor of lower LV GLPS (multivariable regression)
- β = - 0.178, P = 0.01
- EATV independent predictor of lower MEEI (multivariable regression)
- β = - 0.268, P < 0.01
- Share of total negative effect of EATV on GLPS accounted for by reduced MEEI
- ≈29%
- Standardized indirect effect of EATV on GLPS via MEEI
- β = - 0.081, 95% CI - 0.137 to - 0.0029, P < 0.01
Observational data: associations, not effects.
Further findings
- MetS patients had impaired myocardial strain and lower MEEI vs controls
Original publication
Epicardial adipose tissue volume is associated with impaired left ventricular strain in patients with metabolic syndrome: the mediating role of myocardial energetic efficiency. Cardiovasc Diabetol. Published 9 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →