Effects of Sarpogrelate Versus Aspirin on Whole Blood Viscosity in Patients With Type 2 Diabetes and Peripheral Artery Disease
Authors' conclusion
In patients with T2DM and PAD, sarpogrelate did not significantly improve WBV compared with aspirin. VAS scores and cold sensation improved significantly within the sarpogrelate group with no between-group difference.
Study context
- Population
- Adults with T2D and peripheral artery diseaserandomised
- Participants
- 66 adults
- Comparison
- Sarpogrelate vs aspirin
- Sarpogrelaten = 33
- Aspirinn = 33reference
- Primary endpoint
- Change in diastolic whole blood viscosity at a shear rate of 1 s-1 from baseline
- Follow-up
- Week 24
Methodological detailsopen-label
- Open-label
Primary result
As reported in the abstract
Diastolic whole blood viscosity, change from baseline · 24 weeks
| Group | Value | Baseline | Week 24 | Within-group P |
|---|---|---|---|---|
| Sarpogrelate | mean change −1.15 (SD 9.25) | 31.91 ± 7.83 | 30.76 ± 7.08 | p = 0.509 |
| Aspirin | mean change −1.20 (SD 8.36) | 33.32 ± 8.86 | 32.12 ± 9.60 | p = 0.432 |
Value
Sarpogrelatemean change −1.15 (SD 9.25)
Aspirinmean change −1.20 (SD 8.36)
Baseline
Sarpogrelate31.91 ± 7.83
Aspirin33.32 ± 8.86
Week 24
Sarpogrelate30.76 ± 7.08
Aspirin32.12 ± 9.60
Within-group P
Sarpogrelatep = 0.509
Aspirinp = 0.432
Secondary outcomes
| Outcome | Sarpogrelate | Aspirin |
|---|---|---|
| Pain VAS score, change from baseline · 24 weeksMean change | −9.09 (SD 18.09) | −6.13 (SD 16.47) |
| Within-group P | p = 0.007 | p = 0.047 |
| Cold sensation score, change from baseline · 24 weeksMean change | −0.21 (SD 0.55) | −0.23 (SD 0.85) |
| Within-group P | p = 0.033 | p = 0.147 |
Pain visual analogue scale (VAS) score, change from baseline · 24 weeks
- No between-group difference
Cold sensation score, change from baseline · 24 weeks
- Improved only in the sarpogrelate group, with no between-group difference
Original publication
Effects of Sarpogrelate Versus Aspirin on Whole Blood Viscosity in Patients With Type 2 Diabetes and Peripheral Artery Disease. Diabetes Obes Metab. Published 24 August 2026. doi:10.
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