Effects of Prednisolone Administration on Clock Gene Expression and Indices of Circadian Rhythms in Healthy Human Males
Primary result · AUC serum free GC activityResult — go to the resultFold increase 4.5-foldAuthors' conclusion
(1) Prednisolone abrogates the temporal pattern of clock gene expression in human skeletal muscle and adipose tissue. (2) This is accompanied by perturbations of circadian variations in interstitial glucose levels, blood pressure, as well as sleep quality. (3) We hypothesize that adverse effects of high-dose prednisolone treatment are partly mediated by disrupted clocks in metabolic tissues.
Study context
- Population
- Healthy males aged 18 to 34 yearscrossover, 6-week washout
- Participants
- 10 males
- Comparison
- Prednisolone vs placebo
Methodological detailsdouble-blind, crossover
- Double-blind
- Crossover
Primary result
AUC serum free glucocorticoid (GC) activity
Fold increase
4.5-fold
P < 0.001
By group
As reported in the abstract
Further findings
Nocturnal systolic BP · increased with Prednisolone
P = 0.05
Sleep efficiency · reduced with Prednisolone
P = 0.04
Nocturnal vs diurnal interstitial glucose
- Prednisolone increased nocturnal interstitial glucose more than diurnal levels
- 67% (95% CI 36%-97%, P < .001)
Original publication
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