Effect of weight loss through dietary interventions on cardiometabolic health in older adults
Authors' conclusion
Weight loss through dietary interventions with mild calorie restriction resulted in favorable changes in cardiometabolic risk factors among older adults with overweight and obesity.
Study context
- Population
- Overweight adults aged 65–84 with self-reported suboptimal diet, randomized to MIND or control diet (both mild caloric restriction, 250 kcal) for 3 years; mean age 70 (SD = 4.1) years, 65% women, BMI 33.8 (SD = 5.9) kg/m²518 analysed
- Participants
- 604 adults
- Comparison
- Weight-loss categories vs no weight loss
- Primary endpoint
- Cardiometabolic health: lipid biomarkers, inflammation biomarkers and HbA1c
- Follow-up
- Year 3
Methodological detailsLinear mixed-effect models
- Linear mixed-effect models
Primary result
As reported in the abstract
Change in cardiometabolic biomarkers, >10% weight loss vs no weight loss
- LDL cholesterol decreased
- 8.3%
- Triglycerides decreased
- 28.2%
- HDL increased
- 12.4%
- GlycA decreased
- 7.5%
- hs-IL6 decreased
- 33.0%
- hs-CRP decreased
- 59.4%
- Adiponectin increased
- 53.7%
Further findings
Effect modification by dietary intervention
- Improvements in cardiometabolic biomarkers did not differ by dietary intervention
Original publication
Effect of weight loss through dietary interventions on cardiometabolic health in older adults. Int J Obes (Lond). Published 3 October 2025. doi:10.
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