Effect of type-2 diabetes mellitus in long-term mortality in older adults: The NEDICES cohort study
Main finding · MortalityResult — go to the resultAdjusted hazard ratio 1.29 CI 1.16–1.45Authors' conclusion
The sustained reduction in T2DM elderly Spanish subjects' life expectancy address the necessity of community interventions and campaigns regarding lifestyle modifications and reinforce the need for an adequate and regular TDM2 subjects clinical follow-up.
Study context
- Population
- Adults ≥65 years at baseline from three communities (one rural) in central Spain (NEDICES); mean age 73.6 years, 42.5 % male4,998 enrolled
- Participants
- 4,038 adults
- Exposure
- T2D vs no T2D
- T2DMn = 685
- Outcome
- All-cause mortality
- Follow-up
- 1994-95 to 2017
Methodological detailspopulation-based, 22-year follow-up
- Population-based
- 22-year follow-up
Main finding
Mortality · until 2017
Adjusted hazard ratio
1.29
CI 1.16–1.45
T2DMvs non-T2DM
aHR 1.29 (CI 1.16–1.45)
As reported in the abstract
- Overall mortality rate during follow-up
- 85.2 %
Observational data: associations, not effects.
Further findings
Mortality by sex: T2DM vs non-T2DM in men and in women
- Men: HR (T2DM vs non-T2DM)
- HR:1.27; CI 95 %:1.08-1.49;p = 0.005
- Women: HR (T2DM vs non-T2DM)
- HR:1.32; CI 95 %:1.14-1.53;p < 0.001
- No differences between sexes
- P = 0.705
Causes of death in T2DM
- CVD was the most frequent cause of death in T2DM, followed by neoplasm
Overall mortality rate during follow-up
- Mortality rate
- 85.2 %
Original publication
Effect of type-2 diabetes mellitus in long-term mortality in older adults: The NEDICES cohort study. Diabetes Res Clin Pract. Published 4 June 2025. doi:10.
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