Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism
Authors' conclusion
In middle-aged and older men with hypogonadism and low libido, TRT for 2 years improved sexual activity, hypogonadal symptoms, and sexual desire, but not erectile function.
Study context
- Population
- Men aged 45–80 years with 2 testosterone concentrations <300 ng/dL, hypogonadal symptoms, cardiovascular disease (CVD) or increased CVD risk, and low libido, enrolled in the TRAVERSE triallow libido
- Participants
- 1,161 men
- Comparison
- 1.62% testosterone gel vs placebo gel
- Testosterone replacement therapy (TRT)n = 587
- Placebon = 574reference
- Primary endpoint
- Change from baseline in sexual activity score
Methodological detailsnested substudy, placebo-controlled
- Nested substudy
- Placebo-controlled
Primary result
As reported in the abstract
Change in sexual activity · 6 and 12 months
TRT vs PlaceboEstimated mean between-group difference, acts per day (95% CI)P value
6 months; greater improvement with TRT
0.49(0.19,0.79)
omnibus test P = .01112 months; greater improvement with TRT
0.47(0.11–0.83)
omnibus test P = .011Secondary outcomes
Sexual activity · 24 months
- Treatment effect was maintained at 24 months
Hypogonadal symptoms, sexual desire and erectile function
- TRT improved hypogonadal symptoms and sexual desire vs placebo
- TRT did not improve erectile function vs placebo
Original publication
Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism. J Clin Endocrinol Metab. Published 17 August 2023. doi:10.
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