Effect of Growth Hormone Therapy on Pubertal Timing: Systematic Review and Meta-Analysis
Authors' conclusion
Treatment with rhGH appears to promote earlier pubertal timing among children with ISS. Evidence was lacking in children with growth hormone deficiency due to the absence of studies with untreated controls.
Study context
- Population
- Children with idiopathic short stature (ISS) (15 studies), SGA (6), chronic renal failure (3), Noonan syndrome (1) and GHD (1)25 articles
- Participants
- 1,433 children
- Comparison
- Recombinant human growth hormone (rhGH) vs no rhGH
- Outcome
- Pubertal timing
Methodological detailsEmbase, MEDLINE and Cochrane Library searched until December 2021
- Embase, MEDLINE and Cochrane Library searched until December 2021
Pooled result
As reported in the abstract
Pubertal timing, by clinical indication
rhGH vs ControlsMean difference, years (95% CI)
ISS; age at pubertal timing; 9 studies; n total = 397
−0.46(−0.90 to −0.03)
rhGH vs ControlsRelative risk (95% CI)
ISS; pubertal onset during follow-up; 6 studies; n total = 284
1.26(1.03–1.54)
Original publication
Effect of Growth Hormone Therapy on Pubertal Timing: Systematic Review and Meta-Analysis. Horm Res Paediatr. Published 19 April 2023. doi:10.
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