Effect of changes in anthropometric measurements on the remission and progression of prediabetes: A community-based cohort study
Authors' conclusion
Short-term management of BMI and BF% should be emphasized to promote the remission and prevent the progression of prediabetes. Moreover, it is of particular clinical importance to monitor BF% among people with combined IFG and IGT.
Study context
- Population
- Middle-aged and elderly Chinese adults with prediabetes
- Participants
- 3,632 participants
- Exposure
- Per-SD increase in 2.5-year change in body mass index (BMI), BF% and waist circumference (WC)
- Outcome
- Remission to normal glucose regulation (NGR), persistence in prediabetes, or progression to newly diagnosed DM (NDM)
- Follow-up
- 2.5 years
Methodological details2.5-year follow-up
- 2.5-year follow-up
Main finding
As reported in the abstract
- Returned to normal glucose regulation (NGR)
- 16.9%
- Progressed to NDM
- 24.6%
- Remission, RR per SD increase of BMI change
- 0.86 [0.79-0.93]
- Progression, RR per SD increase of BMI change
- 1.15 [1.08-1.23]
- Remission, RR per SD increase of BF% change
- 0.91 [0.84-0.98]
- Progression, RR per SD increase of BF% change
- 1.11 [1.03-1.19]
Observational data: associations, not effects.
Further findings
Remission in combined impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) subgroup
- Only BF% change significantly associated with remission
Original publication
Effect of changes in anthropometric measurements on the remission and progression of prediabetes: A community-based cohort study. Diabetes Res Clin Pract. Published 17 November 2022. doi:10.
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